The planet became a barely habitable sandscape when neighboring Planet Ceti Alpha VI became unstable and exploded. In 2385, Khan took advantage of a U.S.S. Reliant landing party and used it to attack Kirk's Enterprise once again.
In a 22nd century timeline subsequently erased by the successful removal of multiphasic parasites from the brain of Captain Archer, Ceti Alpha V was the last gathering point for straggling human survivors after the Xindi wiped out Earth and all its major colonies in 2163.
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