Ever since you were placed in command of your first starship, you have proven yourself a worthy officer and risen through the ranks. Your crew has served with you to overcome many challenges...
"I don't believe in the no-win scenario; I don't like to lose." - Captain James T. Kirk
The No Win Scenario event was launched in July 2012 as part of STO's Season 6 update. Designed to be a true No Win Scenario, it was stated at the time that players were not expected to progress much further than wave 6 or 7. The mission was not artificially gated, capable of being completed if a team beat all 10 waves. Each wave is progressively more difficult than the last, rewarded by ever-increasing fleet marks for completing each. This can be very profitable way to earn fleet marks for your fleet, if your teammates and you are coordinated enough to conquer the later waves.
In addition to the fleet mark reward, there are six accolades and four titles for players that are able to complete the later waves. Those who are able to beat the final three waves are also rewarded with a server announcement that is broadcast to all the other players playing STO at the time.
The objective of the simulation is for a team of five players to protect a civilian transport for as long as they can from a randomly selected enemy race, which attacks from multiple flanks and multiple waves. As the difficulty level increases, the team also faces a custom-crafted threat for this scenario: Bio-Neural Warhead Platforms. These armed turrets are not only capable of self-repair, but also of firing salvos of armed and highly-damaging Bio-Neural Warheads.
The first team was relieved and excited to beat the No Win Scenario at the end of 2012. A walkthrough was later made available for the community, resulting in the small community of No Win Scenario strategists expanding to take in those interested in defying the odds.
Strategy in a Nutshell

A Crew Working Together

What Makes a Good ‘No Win Scenario’ Build?
There are two important factors to take into consideration: area-of-effect damage and crowd control. The final No Win Scenario wave consists of four flanks of 15 ships, making area-of-effect damage more advantageous than attacking single targets. This favors ships focused on tactical, cannon based powers, with builds taking advantage of abilities such as Cannon Scatter Volley, Torpedo Spread, and various Attack Patterns being more effective.

Tractor Beam Repulsors becomes a multifaceted tool, capable of inflicting direct-to-hull damage in addition to keeping enemies away from the transport. By effectively using Tractor Beam Repulsors, you can not only harm the incoming Bio-Neural Warheads through their shielding but also keep enemies within the firing arc of your forward weapons.
Players will need to survive the combined assaults of both enemy ships and Bio-Neural Warheads; having the means to withstand this combined assault is crucial. Each player should prioritize on healing themselves before healing others or the transport while utilizing equipment that specializes in strong defense and resistances.
Example Build: Fleet Advanced Escort
http://skillplanner.stoacademy.com/?build=nwsfleetadvescort_713 *
• Forward Weapons: Dual/Dual Heavy Cannons and one Torpedo (Romulan Hyper-Plasma Torpedo, Romulan Reputation, is ideal as it draws attention of the warheads).
• Rear Weapons: Turrets (Kinetic Cutting Beam optional).
• Engineering Consoles: Any resistance or universal consoles (e.g. Assimilated console).
• Science Consoles: Any Romulan Science consoles which provide multiple benefits (from the Fleet Embassy holding).
• Tactical Consoles: Energy weapon damage consoles.
• Ship Equipment: M.A.C.O. Shield/Deflector/Engines (Omega Reputation, an ideal defensive set which also provides the player with a Heavy Graviton Beam which is excellent for saving a single ship).
*This setup can be closely applied to other ships such as the Romulan Dhelan Warbird and the Klingon Birds-of-Prey.
Conclusion and Final Words

For detailed information on how to deal with the No Win Scenario, I highly recommend reading the walkthrough (http://sto.gamepedia.com/Mission:_No_Win_Scenario/Walkthrough) which has helped teams progress further and even beat the event. Thank you to the people whose contributions and support helped beat the No Win Scenario, with a special thank you to The_Epsilonian for his collaboration in writing this blog.
I wish you the best of luck!
-@V_Silverwings