Seth MacFarlane strikes again. In Sunday night's season premiere of Family Guy, he couldn't resist riffing on Star Trek once more — and he had the help of Patrick Stewart, Jonathan Frakes and Michael Dorn.

In one of the show's frequent non sequiturs, Peter Griffin (voiced by MacFarlane) makes the comment, "Boy, I haven't been this creeped out since I saw that episode of Star Trek." Then it cuts to an animated Enterprise-D in orbit over a planet, and then to Captain Picard's bridge, complete with an animated Riker, Troi, La Forge, Worf, Data and Wesley Crusher at stations.

Picard (voiced by Stewart) says to Riker, "Number One ... let me ask you something. If I whispered in your ear that Commander Worf's head looks like a fanny, would you join me in a laugh?" Riker (Frakes) says, "Yeah, I could get in on that!" Picard: "All right! Here it comes!" He then says loudly, "Commander Worf's head looks like a fanny!" and the whole bridge laughs. Except for Worf (Dorn), who responds, "You can both suck my ridges!" Picard comes back, "Oh, get a sense of humor, Rocky Dennis!" (A reference to the movie "Mask.")

Those who stayed tuned for the next half-hour also heard Stewart's voice in the season premiere of American Dad, another MacFarlane creation. Stewart plays the recurring role of CIA deputy director "Bullock" — and his animated character looks precisely like him.

MacFarlane is an avid Star Trek fan, and got himself two cameo appearances on Star Trek: Enterprise — in "The Forgotten" and "Affliction."

David A. Goodman, a former writer on Enterprise, is also an executive producer on Family Guy.