A Constitution-class Federation starship, registry no. NCC-1631, with an all-Vulcan crew destroyed in 2268 by a gigantic spaceborne amoeba creature near the Gamma 7A System.

A year earlier, the Intrepid had been given second priority after the eU.S.S. Enterprise when both ships were docked in maintenance section 18 at Starbase 11.

Reference: The Immunity Syndrome