That quarter of the Milky Way Galaxy appearing to be located between 6 and 9 o'clock if the great plane of the galaxy is viewed as a clockface and the 6 o'clock position bisects the Sol system.

The quadrant is home to the bulk of the Federation and the Cardassian Union, along with Bajor and its adjacent wormhole which bridges a 70,000-lightyear shortcut to the Gamma Quadrant.