Herb Solow joined the mailroom of the William Morris Agency in New York City shortly after graduation from Dartmouth College in 1953. After his promotion to talent agent in 1956, Solow moved to NBC as Program Director of California National Productions and its subsidiary, the NBC Film Division, which was the network's in-house film unit. In 1960 Solow was transferred to Los Angeles, shortly before NBC, reacting to government regulations relative to network ownership of syndication companies, dissolved the NBC Film Division.

Solow then joined CBS as Director of Daytime Programs, West Coast, subsequently returning to NBC a year later as Director of Daytime Programs.

He left his NBC Daytime Programs position and joined Desilu Studios in 1964. Appointed Vice President of Production a year later, Solow personally oversaw the development, sales, and production of Star Trek, Mission Impossible, and Mannix.

After Desilu was sold to Gulf & Western and combined with Paramount Studios, Solow joined Metro-Goldwyn-Mayer as Vice President of Television Production, overseeing the development and series production of Medical Center, The Courtship of Eddie's Father, and Then Came Bronson.

Solow was subsequently appointed Vice President of Worldwide Motion Picture and Television Production for MGM. During that period, he hired Gene Roddenberry to write and produce a theatrical film, "Pretty Maids All in a Row," based on the novel by Francis Pollini and directed by Roger Vadim. Among the other films made under his helm at MGM were "Ryan's Daughter," directed by David Lean; "Brewster McCloud," directed by Robert Altman; "Shaft," directed by Gordon Parks; "Zabriskie Point," directed by Michelangelo Antonioni; "Kelly's Heroes," directed by Bryan Hutton; "Alice in Wonder Land," directed by Paul Mazursky; "The Strawberry Statement," directed by Stuart Hagmann; and "The Gang That Couldn't Shoot Straight," directed by Star Trek pilot director James Goldstone.

In 1973, he left MGM to become an independent filmmaker and formed Solow Productions. He co-created and produced the television series Man from Atlantis. He was also involved in the production of the English movie "Brimstone and Treacle," written by Dennis Potter and starring Sting, Joan Plowright, and Denham Elliot. His last feature film production was "Saving Grace," starring Tom Conti, Giancarlo Giannini, and Edward James Olmos.

Solow is a member of the Writers Guild of America and the Directors Guild of America and serves on the Foreign Film, Documentary, and Special Effects Committees of the Academy of Motion Picture Arts and Sciences. He is currently an independent writer-producer and also lectures on television and film production.