A Federation starship of late 24th-century design.

In an alternate timeline (where the U.S.S. Voyager was lost for 23 years, rather than seven), Ensign Harry Kim was eventually promoted to captain and given command of the U.S.S. Rhode Island. Captain Kim took the Rhode Island on a four-year deep space assignment, which took place circa 2400.

In 2404, Captain Kim took the Rhode Island to intercept Admiral Kathryn Janeway and avert her attempt to change history. Kim did this without informing Starfleet, and while telling his crew that he needed to take Janeway back to Starfleet Medical because she had contracted a rare disease known to affect judgment. Rather than stopping her, though, Kim allowed Janeway to use a chrono-deflector to make a one-way trip back in time.

The Rhode Island also aided Janeway against a pair of Klingon warships that attempted to destroy her shuttle.