- Star Trek: The Motion Picture
- Star Trek II: The Wrath of Khan
- Star Trek III: The Search for Spock
- Star Trek IV: The Voyage Home
- Star Trek V: The Final Frontier
- Star Trek VI: The Undiscovered Country
- Star Trek Generations
The U.S.S. Defiant succesfully acompanied this freighter convoy to the Vegan System in 2374. On the way home, they picked up Captain Lisa Cusak's distress signal.