- Star Trek: The Motion Picture
- Star Trek II: The Wrath of Khan
- Star Trek III: The Search for Spock
- Star Trek IV: The Voyage Home
- Star Trek V: The Final Frontier
- Star Trek VI: The Undiscovered Country
- Star Trek Generations
This kind of Federation starship is often used for scientific missions.
At the Battle of Wolf 359, an Oberth-class starship, in the Saratoga's battle group, was destroyed by the Borg. While trying to rescue his son, Sisko could see the ship's destruction through the portals of his quarters.