- Star Trek: The Motion Picture
- Star Trek II: The Wrath of Khan
- Star Trek III: The Search for Spock
- Star Trek IV: The Voyage Home
- Star Trek V: The Final Frontier
- Star Trek VI: The Undiscovered Country
- Star Trek Generations
In 2270 (stardate 5275.6), Spock invokes Starfleet General Order #6 when the entire Enterprise crew except himself has been stricken with the deadly Dramian plague. According to Helmsman Sulu, the order is, "If everyone onboard has perished at the end of 24 hours, the ship will self-destruct in order to protect other beings from the disease onboard."