Deprival of sleep from the "rapid-eye movement" phase restricts dreaming and causes the loss of concentration and cognitive abilities. Paranoia, hallucinations, and insanity are all common symptoms. While in a Tyken's Rift, the U.S.S. Enterprise NCC-1701-D crew's REM sleep was disrupted by the telepathic distress signals sent by an alien crew similarly stranded.
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