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An incurable terminal disease which attacks the brain and central nervous system.  Symptoms visible by its final stage include coughing, pain, shortness of breath, and irritability and other erratic behavior.

In 2365, Dr. Ira Graves suffered from its final stage when he was checked by the U.S.S. Enterprise NCC-1701-D. Though still ambulatory, he was given no more than a week to live.