Jeffrey Combs has played numerous characters in the Star Trek universe, appearing in Deep Space Nine, Voyager, and Enterprise. His most notable roles are as Weyoun the Vorta and the Ferengi Brunt on Deep Space Nine as well as Commander Shran on Enterprise.

Outside of Star Trek, Combs is best known for appearing in several movies based on books by H.P. Lovecraft, including 1985's "Re-Animator."