I would like to see a new series with the Odyssey-class Enterprise-F from the online game or even skip to the YouTube D.J. Curtis Eclipse-class Enterprise-"Golf". I don't know if there's a developed backstory for the "Foxtrot" iteration, so excuse my using my own imagination here. I would see other ideas that people might have and your casting choices.
Main casting -
Angela Bassett as the Human Captain, though I wouldn't mind seeing a non-human captain. You could make her a Trill or Betazoid I suppose.
Jason Statham as the Andorian First Officer.
Justin Long as the Benzite Science Officer.
Brian Uhrlacher as the Human Security Chief.
Keenan Thompson as the Denobulan Chief Medical Officer.